Single brain scan predicts tipping point for symptom onset in Alzheimer’s


“Researchers at Washington University School of Medicine in St Louis have developed an algorithm-based approach, using data from a kind of brain scan known as amyloid positron emission tomography (PET) to gauge brain levels of the key Alzheimer's protein amyloid beta.

Amyloid PET scans are used widely in Alzheimer's research, and this algorithm represents a new way of analysing such scans to approximate when symptoms will arise. 

The power of this new technique is that it requires just one brain scan, plus the person's age. With that data, the model can estimate the time to symptom onset, plus or minus several years. In this study, the correlation between the expected age of symptom onset and the true age at diagnosis was better than 0.9 on a scale of 0 (no correlation) to 1 (perfect correlation).” – MedicalBrief (30 September 2021)

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